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CURRICULUM VITAE

1a. Personal details

Title(s), initial(s), first name, surname:

J.W. Berkelbach van der sprenkel, MD, Phd

male

17-08-1957

Nationality:

Netherlands

1b. Master's (‘doctoraal’)

University/College of Higher Education:

Medial School: University Medical School Utrecht (1976-1983)

Neurosurgical training:

Department of Neurosurgery UMC Utrecht (prof. Dr.C.A.F. Tulleken1988-1994)

Neurological training Department of Neurologie UMC Utrecht (prof. Dr. J. van

Gijn 1989-1990)

Surgical Training Department of Surgery, Westeinde Ziekenhuis Den Haag,

(Dr. R. Koumans 1990-1991)

1c. Doctorate

University/College of Higher Education:

Thesis (PHD-degree) Functional and metabolic aspects of cerebral ischemia

(16-6-1988) Promotor Prof. Dr. C.A.F. Tulleken and Prof. Dr. F.H.

Lopes da Silva, Co-promotor: Dr. E.J.Jonkman

2. Use of extension clause: yes/no

(see procedure, if yes give reason and calculation)

3. Current employment

- Type of contract:

Current position

Fixed term

Permanent

Assistant professor (UHD)

0.8 FTE

4. Work experience since completing your PhD

Research position Department of Neurosurgery UMC Utrecht (1984-1988)

Fellowship NMR in Biomedicine (1986) (A. Bénabid, Grenoble)

Neurosurgical appointments:

UMC Utrecht, junior staff member (1994 –2000)

Central Military Hospital Utrecht (1996- 1998)

Meander Medical Centre Baarn (1997- 2009)

UMC Utrecht, Chef de Clinique ( 2000- )

St Jansdal Hospital, Harderwijk ( 2009- )

Other appointments:

Interim Head Department of Neurosurgery (2002-2007)

Director Neurosurgical training program (2004- )

5. Co-promotor phd thesis

Name/ funding

Title thesis

Date of defence

Dr. H.B. Verheul

Janivo stichting

Experimental cerebral ischemia. Temporal evolution of cell death.

1994

Dr. R.M. Dijkhuizen

Janivo stichting

Magnetic resonance imaging and spectroscopy in experimental cerebral ischemia.

1998

Dr. P.W.A. Willems

Schumacher Kramer Stichting

Technical and clinical assessment of Neuronavigation

2005

Dr. P.H. Woerdeman

Frameless Image guided Neurosurgery in motion

2008

Dr. M.P.A. van Meer

Alexander Suerman programma

Brain reorganization after experimental strok: Functional and Structural MRI correlates

2011

Drs. E.H. Voormolen

Alexander Suerman Programma/ Zon MW. / Medtronic

Current Promovendus

6. Composition own research group

Current promovendus: Drs. E.H. Voormolen.

Close collaboration with BTI- Elana.

International collaboration with Medtronic (Boulder USA)

7. Brief summary of research over the last five years (max ½ A4)

Current research is focussed on the use of Neuronavigation in skull base surgery. Semi- automatic routines have been developed to inform the surgeon about surgical boundaries and no go area’s. In real time surgical instruments can be followed. On line information is obtained about the extent of resection. The research is performed in collaboration with the BrainTechnologyInstitute – Elana where, with a grant from Zon- MW, a model has been developed in which human cadavers are perfused with artificial blood. In this way surgical approaches can be done on cadaver material, that is “bleeding” when blood vessels are opened, thereby resembling real surgery in a most unconventional training environment. In the next year the clinical application will be tested in close collaboration with the ENT department. The next step in the research will be the clinical application of this module in patients undergoing mastoidectomy for cochlear implants. The perspective of this research is to proceed to robotic applications that use the basic principle of this research.

8. Education qualifications: BKO/SKO

Head of the training program Department of Neurosurgery ( 2004- )

Train the trainer I, II and III

9. International activities

Member of the European Association of Neurosurgical Societies (EANS) Research Committee

10. Other academic activities

Member of the Consilium Neurochirurgicum

Chairman Research Committee NVVN

Member Raad Wetenschap, Federatie Medisch Specialisten

11.Scholarships, grants and prizes

Funding from:

Zon MW,

Alexander Suerman,

Schumacher Kramer Stichting

Janivo Stiching

Research navigator from Medtronic

12. Publications Dr. J.W. Berkelbach van der Sprenkel

70 publications

6 primary author

40 contributing author

24 senior author

1531 citations

H-index 22

Key publications

J. M. Biesbroek, J. W. van der Sprenkel, A. Algra, and G. J. Rinkel. Prognosis of acute subdural haematoma from intracranial aneurysm rupture. J.Neurol.Neurosurg.Psychiatry 84 (3):254-257, 2013.

J. M. Biesbroek, G. J. Rinkel, A. Algra, and J. W. van der Sprenkel (2012). Risk factors for acute subdural hematoma from intracranial aneurysm rupture. Neurosurgery 71 (2):264-268.

E. H. Voormolen, P. A. Woerdeman, Stralen M. van, H. J. Noordmans, M. A. Viergever, L. Regli, and J. W. van der Sprenkel (2012). Validation of exposure visualization and audible distance emission for navigated temporal bone drilling in phantoms. PLoS.One. 7 (7):e41262.

Woerdeman, P.A., Willems, P.W.A., Noordmans, H.J., Tulleken, C.A.F. & Berkelbach van der

Sprenkel, J.W. (2007). Application accuracy in frameless image-guided neurosurgery: a comparison study of three patient-to-image registration methods. Journal of Neurosurgery, 106, 1012-1016.

Woerdeman, P.A., Willems, P.W., Noordmans, H.J., & Berkelbach van der Sprenkel, J.W.

(2009). Auditory feedback during frameless image-guided surgery in a phantom model and initial clinical experience. Journal of Neurosurgery, 110(2), 257-262.

Complete List of Publications

2015

Maaike S. M. van Mourik, Annet Troelstra, Jan Willem Berkelbach van der Sprenkel, Marischka C. E. van der Jagt. Validation of an Automated Surveillance Approach for Drain-Related Meningitis: A Multicenter Study. Infection Control and Hospital Epidemiology; Volume 36 (Issue 01 / January 2015):65 - 75.

2014

Janneke van Beijnum, H Bart van der Worp, Ale Algra, W Peter Vandertop, René van den Berg, Patrick A Brouwer, Jan Willem Berkelbach van der Sprenkel, L Jaap Kappelle, Gabriël J E Rinkel, Catharina J M Klijn Prevalence of Brain Arteriovenous Malformations in First-Degree Relatives of Patients With a Brain Arteriovenous Malformation. Stroke. 2014; 45: 3231-3235

Available from: Christian Stapf

Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial

J. P. Mohr, Michael K Parides, Christian Stapf, Ellen Moquete, Claudia S Moy, Jessica R. Overbey, Rustam Al-Shahi Salman, Eric Vicaut, William L. Young, Emmanuel Houdart, [......], J. I. Lopez, J. Biller, M. Schneck, D. Anderson, S. Cullen, V. Rao, N. Moayeri, V. Tse, A. P. Jr Bowles, K. Nassr. On behalf of the studygroup. The Lancet 01/2014; 383(9917):614–621.

2013

J. M. Biesbroek, J. W. van der Sprenkel, A. Algra, and G. J. Rinkel. Prognosis of acute subdural haematoma from intracranial aneurysm rupture. J.Neurol.Neurosurg.Psychiatry 84 (3):254-257, 2013.

2012

J. M. Biesbroek, G. J. Rinkel, A. Algra, and J. W. van der Sprenkel (2012). Risk factors for acute subdural hematoma from intracranial aneurysm rupture. Neurosurgery 71 (2):264-268.

M. P. van Meer, W. M. Otte, K. van der Marel, C. H. Nijboer, A. Kavelaars, J. W. van der Sprenkel, M. A. Viergever, and R. M. Dijkhuizen (2012). Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity. J.Neurosci. 32 (13):4495-4507.

E. H. Voormolen, Stralen M. van, P. A. Woerdeman, J. P. Pluim, H. J. Noordmans, M. A. Viergever, L. Regli, and Berkelbach van der Sprenkel JW (2012). Determination of a facial nerve safety zone for navigated temporal bone surgery. Neurosurgery 70 (1 Suppl Operative):50-60.

E. H. Voormolen, Stralen M. van, P. A. Woerdeman, J. P. Pluim, H. J. Noordmans, M. A. Viergever, L. Regli, and Berkelbach van der Sprenkel JW (2012).Determination of a facial nerve safety zone for navigated temporal bone surgery. Neurosurgery 70 (1 Suppl Operative):50-60, discussion 60.

M.S.M. van Mourik, K.G.M. Moons, W.W.van Solinge, J.W. Berkelbach van der Sprenkel, L. Regli, et al. (2012) Automated Detection of Healthcare Associated Infections: External Validation and Updating of a Model for Surveillance of Drain-Related Meningitis. PLoS ONE 7(12): e51509. doi:10.1371/journal.pone.0051509

2011

Mourik, M.S. van, Groenwold, R.H, Berkelbach van der Sprenkel, J.W., Solinge, W.W., van, Troelstra, A. en Bonten, M.J. (2011). Automated detection of external ventricular and lumbar drain-related meningitis using laboratory and microbiology results and medication data 1. PLoS.One. 6 (8):e22846.

Beijnum, J. van, Worp, H.B., van der, Buis, D.R., Salman, R. al-Shahi, Kapelle, L.J., Rinkel, G.J., Sprenkel, J.W., van der, Vandertop, W.P., Algra, A. and Klijn, C.J. (2011). Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA 306 (18):2011-2019.

Meer, M.P. van der, Marel, K. van der, Sprenkel, J.W. van der en Dijkhuizen, R.M. (2011). MRI of bilateral sensorimotor network activation in response to direct intracortical stimulation in rats after unilateral stroke. J.Cereb.Blood Flow Metab 31 (7):1583-1587.

Saeed, P., Furth, W.R. van, Tanck, M., Freling, N., Sprenkel, J.W. van der, Stalpers, L.J., Overbeeke, J.J. van and Mourits, M.P. (2011). Surgical treatment of sphenoorbital meningiomas. Br.J.Ophthalmol. 95 (7):996-1000.

Saeed, P., Furth, W.R. van Furth, Tanck, M. Kooremans, F., Freling, N., Steekstra, G.I., Regensburg, N.I., Sprenkel, J.W., van der, Peerdeman, M. Overbeeke, J.J. van and Mourits, M.P. (2011). Natural history of spheno-orbital meningiomas. Acta Neurochir.(Wien.) 153 (2):395-402.

2010

Doormaal, T.P. van, Zwan, A. van der, Aboud, E., Berkelbach van der Sprenkel, J.W., Tulleken,

C.A., Krisht, A.F., & Regli, L. (2010). The sutureless excimer laser assisted non-occlusive anastomosis (SELANA); a feasibility study in a pressurized cadaver model. The European Journal of Neurosurgery, 152(9), 1603-1608.

Leverstein-van Hall, M.A., Hopmans, T.E., Berkelbach van der Sprenkel, J.W., Blok, H.E.,

Mark, W.A. van der, Hanlo, P.W., & Bonten, M.J. (2010). A bundle approach to reduce the incidence of external ventricular and lumbar drain-related infections. Journal of Neurosurgery, 112(2), 345-353.

Meer, M.P. van, Marel, K. van der, Otte, W.M., Berkelbach van der Sprenkel, J.W., &

Dijkhuizen, R.M. (2010). Correspondence between altered functional and structural connectivity in the contralesional sensorimotor cortex after unilateral stroke in rats: a combined resting-state functional MRI and manganese-enhanced MRI study. Journal of Cerebral Blood Flow & Metabolism, 30(10), 1707-1711.

Meer, M.P. van, Marel, K. van der, Wang, K., Otte, W.M., El Bouazati, S., Roeling, T.A.,

Viergever, M.A., Berkelbach van der Sprenkel, J.W., & Dijkhuizen, R.M. (2010). Recovery of sensorimotor function after experimental stroke correlates with restoration of resting-state interhemispheric functional connectivity. Journal of Neuroscience, 30(11), 3964-3972.

Saeed, P., Furth, W.R. van, Tanck, M., Kooremans, F., Freling, N., Streekstra, G.I., Regensburg,

N.I., Berkelbach van der Sprenkel, J.W., Peerdeman, S.M., Overbeeke, J.J. van, & Mourits, M.P. (2010). Natural history of spheno-orbital meningiomas. Acta Neurochirurgica, [Epub ahead of print].

2009

Woerdeman, P.A., Willems, P.W., Noordmans, H.J., Tulleken, C.A., & Berkelbach van der

Sprenkel, J,W. (2009). The impact of workflow and volumetric feedback on frameless image-guided neurosurgery. Neurosurgery, 64(3 Suppl), 170-175.

Woerdeman, P.A., Willems, P.W., Noordmans, H.J., & Berkelbach van der Sprenkel, J.W.

(2009). Auditory feedback during frameless image-guided surgery in a phantom model and initial clinical experience. Journal of Neurosurgery, 110(2), 257-262.

2007

Beijnum, J. van, Worp, H.B. van der, Schippers, H.M., Nieuwenhuizen, O. van, Kappelle, L.J.,

Rinkel, G.J.E., Berkelbach van der Sprenkel, J.W., & Klijn, C.J.M. (2007). Familial occurrence of brain arteriovenous malformations: a systematic review. Journal of Neurology, Neurosurgery and Psychiatry, 78(11), 1213-1217.

Willems, P.W.A., Walsum, T. van, Woerdeman, P.A., Kraats, E.B. van de, Kort, G.A.P. de,

Niessen, W.J., & Berkelbach van der Sprenkel, J.W. (2007). Image-guided vascular neurosurgery based on three-dimensional rotational angiography. Technical note. Journal of Neurosurgery, 106(3), 501-506.

Woerdeman, P.A., Willems, P.W.A., Noordmans, H.J., Tulleken, C.A.F. & Berkelbach van der

Sprenkel, J.W. (2007). Application accuracy in frameless image-guided neurosurgery: a comparison study of three patient-to-image registration methods. Journal of Neurosurgery, 106, 1012-1016.

Woerdeman, P.A., Willems, P.W.A., Noordmans, H.J., & Berkelbach van der Sprenkel, J.W.

(2007). The effect of repetitive manual fiducial localization on target localization in image space. Neurosurgery, 60(2), 100-104.

2006

Mark, W.A. van der, Beijnum, J. van, Blok, H.E.M., Bonten, M.J.M., Hopmans, T.,

Rutten, G.J.M., Hanlo, P.W., Leverstein-van Hall, M.A., & Berkelbach van der Sprenkel, J.W. (2006). Reducing secondary meningitis in patients with extraventricular and extralumbar drains. Abstract European Society for Pediatric Neurosurgery Congress 2006.

Willems, P.W.A., Taphoorn, M.J.B., Burger, H., Berkelbach van der Sprenkel, J.W., &

Tulleken, C.A.F. (2006). Effectiviness of neuronavigation in resecting solitary intracerebral contrast-enhancing tumors: a randomized controlled trial. Journal of Neurosurgery, 104(3), 360-368.

Willems, P.W.A., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., Viergever, M.A., &

Taphoorn, M.J.B. (2006). Neuronavigation and surgery of intracerebral tumours. Journal of Neurology, 253(9), 1123-1136.

Willems, P.W.A., & Berkelbach van der Sprenkel, J.W. (2006). Neuronavigation in solitary

intracerebral tumours - Response. Journal of Neurosurgery, 105(5), 803.

Woerdeman, P.A.W., Willems, P.W.A., Noordmans, H.J., & Berkelbach van der Sprenkel,

J.W. (2006). Clinical accuracy of neuronavigation using registration methods based on points-pairs or surface matching. International Journal of Computer Assisted Radiology and Surgery 1(Suppl 7), 297-299.

Woerdeman, P.A., & Willems, P.W.A., Noordmans, H.J., & Berkelbach van der Sprenkel, J.W.

(2006). The analysis of intraoperative neurosurgical instrument movement using a navigation log-file. The international Journal of Medical Robotics + Computer Assisted Surgery, 2(2),139-145.

Woerdeman, P.A., Willems, P.W., Noordmans, H.J., Berkelbach van der Sprenkel, J.W., &

Rijen, P.C. van. (2006). Frameless stereotactic subcaudate tractotomy for intractable `

obsessive-compulsive disorder. Acta neurochirurgica, 148(6), 633-637.

Woerdeman, P.A., Willems, P.W.A., Noordmans, H.J., & Berkelbach van der Sprenkel, J.W.

(2006). Postoperative analysis of surgical instrument movement using a navigation log-file. International Journal of Computer Assisted Radiology and Surgery, 1(Suppl 7), 304-307.

2005

Streefkerk, H.J.N. (2005). The ELANA technique: Applicability in Experimental and Clinical

Settings. Proefschrift UU Universiteit Utrecht. Prom: prof. dr C.A.F. Tulleken & prof. dr B. Hillen, Co-prom.: dr J.W. Berkelbach van der Sprenkel & dr M.J.B. Taphoorn.

Willems, P.W.A. (2005). Technical and clinical assessment of neuronavigation.

Proefschrift UU Universiteit. Prom.: prof. dr C.A.F. Tulleken & prof. dr ir M.A. Viergever.

Co-prom.: dr J.W. Berkelbach van der Sprenkel & dr M.J.B. Taphoorn.

Willems, P.W.A., Noordmans, H.-J., Overbeeke, J.J. van, Viergever, M.A., Tulleken, C.A.F., &

Berkelbach van der Sprenkel, J.W. (2005). The impact of auditory feedback on neuronavigation. Acta Neurochirurgica, 147(2), 167-173.

Woerdeman, P.A.W., Willems, P.W.A., Han, K.S., Hanlo, P.W., & Berkelbach van der

Sprenkel, J.W. (2005). Frameless stereotactic placement of ventriculoperitoneal shunts in undersized ventricles: a simple modification to free-hand procedures. British Journal of Neurosurgery, 19(6), 484-487.

2004

Letteboer, M.M.J., Hellier, P., Rueckert, D., Willems, P.W.A., Berkelbach van der Sprenkel,

J.W., & Niessen, W.J. (2004). Non-rigid registration of intraoperatively acquired 3D ultrasound data of brain tumours. In Buzug, T.M., & Lueth, T.C. (Eds.), Perspective in Image-Guided Surgery: Proceedings Of The Scientific Workshop On Medical Robotics, Navigation And Visualization (pp. 11-18). Singapore: World Scientific Publishing Co. Pte. Ltd.

2003

Bergh, W.M. van den, Albrecht, K.W., Berkelbach van der Sprenkel, J.W., & Rinkel, G.J.E.

(2003). Magnesium therapy after aneurysmal subarachnoid haemorrhage; a dose-finding study for long term treatment. Acta Neurochirurgica, 145(3), 195-199.

Bergh, W.M. van den, Algra, A., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., & Rinkel,

G.J.E. (2003). Hypomagnesemia after aneurysmal subarachnoid hemorrhage. Neurosurgery, 52(2), 276-281.

Rutten, G.J.M., Ramsey, N.F., Noordmans, H.J., Willems, P.W.A., Rijen, P.C. van, Berkelbach

van der Sprenkel, J.W., Viergever, M.A., & Veelen, C.W.M. van (2003). Toward functional neuronavigation: Implementation of functional magnetic resonance imaging data in a surgical guidance system for intraoperative identification of motor and language cortices. Technical note and illustrative case. Neurosurgical Focus, 15(1), 1-6.

Willems, P.W.A., Noordmans, H.J., Berkelbach van der Sprenkel, J.W., Overbeeke, J.J. van,

Viergever, M.A., & Tulleken, C.A.F. (2003). The impact of auditieve feedback on neuronavigation. In Lemke, H.U., Vannier, M.W., Inamura, K., Farman, A.G., Doi, K., & Reiber, J.H.C.(Eds.), Computer assisted radiology and surgery (CARS). Proceedings of the 17th International Congress and Exhibition (pp. 476-481). Amsterdam: Elsevier.

Willems, P.W.A., Noordmans, H.J., Ramos, L.M.P., Taphoorn, M.J.B., Berkelbach van der

Sprenkel, J.W., Viergever, M.A., & Tulleken, C.A.F. (2003). Clinical evaluation of stereotactic brain biopsies with an MKM-mounted instrument holder. Acta Neurochirurgica, 145(10), 889-897.

2002

Willems, P.W.A., Noordmans, H.J., Berkelbach van der Sprenkel, J.W., Viergever, M.A., &

Tulleken, C.A.F. (2002). Monte Carlo stimulation of anisotropic error prediction in frameless stereotaxy. In Lemke, H.U., Vannier, M.W., Inamura, K., Farman, A.G., Doi, K., & Reiber, J.H.C. (Eds.), Proceedings of the 16th International Congress and Exhibition on “Computer Assisted Radiology and Surgery” (pp.1072). Berlin: Springer.

2001

Mourits, M.P., & Berkelbach van der Sprenkel, J.W. (2001). Orbital meningioma, the Utrecht

experience. Orbit, 20(1), 25-33.

Velthuis, B.K., Leeuwen, M.S. van, Witkamp, T.D., Ramos, L.M.P., Berkelbach van der

Sprenkel, J.W., & Rinkel, G.J.E. (2001). Surgical anatomy of the cerebral arteries in patients with subarachnoid hemorrhage: comparison of computerized tomography angiography and digital substraction angiography. Journal of Neurosurgery, 95(2), 206-212.

Willems, P.W.A., Berkelbach van der Sprenkel, J.W., Taphoorn, M.J.B., & Tulleken, C.A.F.

(2001). Neuronavigatie. Nederlands Tijdschrift voor Neurologie, 4, 281-289.

Willems, P.W.A., Berkelbach van der Sprenkel, J.W., & Tulleken, C.A.F. (2001). Comparison

of adhesive markers, anatomical landmarks and surface matching in patients-to-image registration for frameless stereotaxy. In Gannot, I., Gulyaev, Y.V., Papazoglou, T.G., & Swol, C.F.P. van (Eds.), Proceedings of the Society of Photo-Optical Instrumentation Engineers (SPIE) (vol. 4158) (pp. 156-163).

Willems, P.W.A., Noordmans, H.J., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., &

Viergever, M.A. (2001). Robot assisted point-stereotactic neurosurgery: phantom evaluation and early clinical experience. In McCulloch, G.M., & Reilly, P. (Eds.), Proceedings of the 12th World Congress of Neurosurgery, Sydney, Australia, September 16-20, 2001 (pp. 348-352). Adelaide: Neurosurgical Society of Australasia Research Foundation.

Willems, P.W.A., Noordmans, H.J., Berkelbach van der Sprenkel, J.W., Viergever, M.A., &

Tulleken, C.A.F. (2001). An MKM-mounted instrument holder for frameless point-stereotactic procedures: a phantom-based accuracy evaluation. Journal of Neurosurgery, 95(6), 1067-1074.

Willems, P.W.A., Noordmans, H.J., Berkelbach van der Sprenkel, J.W., Viergever, M.A., &

Tulleken, C.A.F. (2001). Robot-ondersteunde stereotactische neurochirurgie.

Nederlands Tijdschrift voor Geneeskunde, 145, 2004-2005.

2000

Hop, J.W., Rinkel, G.J.E., Algra, A., Berkelbach van der Sprenkel J.W., & Gijn, J. van (2000).

Randomized pilot trial of postoperative aspirin in subarachnoid hemorrhage. Neurology, 54(4), 872-878.

1999

Dijkhuizen, R.M., Beekwilder, J.P., Worp, H.B. van der, Berkelbach van der Sprenkel, J.W.,

Tulleken, K.A., & Nicolay, K. (1999). Correlation between tissue depolarizations and damage in focal ischemic rat brain. Brain Research, 840(1-2), 194-205.

1998

Dijkhuizen, R.M., Knollema, S., Worp, H.B. van der, Horst, G.J. ter, Wildt, D.J. de, Berkelbach

van der Sprenkel, J.W., Tulleken, K.A., & Nicolay, K. (1998). Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. Stroke, 29(3), 695-704.

Velthuis, B.K., Rinkel, G.J., Ramos, L.M., Witkamp, T.D., Berkelbach van der Sprenkel, J.W.,

Vandertop, W.P., & Leeuwen, M.S. van (1998). Subarachnoid hemorrhage: aneurysm detection and preoperative evaluation with CT angiography. Radiology, 208(2), 423-430.

1997

Dijkhuizen, R.M., Berkelbach van der Sprenkel, J.W., Tulleken, K.A., & Nicolay, K. (1997).

Regional assessment of tissue oxygenation and the temporal evolution of hemodynamic parameters and water diffusion during acute focal ischemia in rat brain. Brain Research, 750(1-2), 161-170.

1994

Toorn, A. van der, Verheul, H.B., Berkelbach van der Sprenkel, J.W., Tulleken, C.A., & Nicolay,

K. (1994). Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy. Magnetic Resonance in Medicine, 32(6), 685-691.

Verheul, H.B., Balázs, R., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., Nicolay, K.,

Tamminga, K.S., & Lookeren Campagne, M. van (1994). Comparison of diffusion-weighted MRI with changes in cell volume in a rat model of brain injury. NMR in Biomedicine, 7(1-2), 96-100.

1993

Verheul, H.B., Balázs, R., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., Nicolay, K., &

Lookeren Campagne, M. van (1993). Temporal evolution of NMDA-induced excitoxicity in the neonatal rat brain measured with 1H nuclear magnetic resonance imaging.

Brain Research, 618(2), 203-212.

1992

Berkelbach van der Sprenkel, J.W., Knufman, N.M., Rijen, P.C. van, Luyten, P.R., Hollander,

J.A. den, & Tulleken, C.A.F. (1992). Proton spectroscopic imaging in cerebral ischaemia. Where we stand and what can be expected. Advances and Technical Standards in Neurosurgery, 19, 3-17.

Verheul, H.B., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., Tamminga, K.S., &

Nicolay, K. (1992). Temporal evolution of focal cerebral ischemia in the rat assessed by T2-weighted and diffusion-weighted magnetic resonance imaging. Brain Topography, 5(2), 171-176.

1990

Jaspers, R.M., Berkelbach van der Sprenkel, J.W., Tulleken, C.A.F., & Cools, A.R. (1990).

Local as well as remote functional and metabolic changes after focal ischemia in cats.

Brain Research Bulletin, 24(1), 23-32.

1989

Jaspers, R.M., Berkelbach van der Sprenkel, J.W., & Cools, A.R. (1989). Progressive

pathology of the caudate nucleus, the substantia nigra pars reticulata and the deeper layers of the colliculus superior: acute behavioural and metabolic effects of intrastriatal kainic acid. Neuroscience, 28(1), 159-169.

Rijen, P.C. van, Luyten, P.R., Berkelbach van der Sprenkel, J.W., Kraaier, V., Huffelen, A.C.

van, Tulleken, C.A.F., & Hollander, J.A. den (1989). 1H and 31P NMR measurement of cerebral lactate, high-energy phosphate levels, and pH in humans during voluntary hyperventilation: associated EEG, capnographic, and Doppler findings. Magnetic Resonance in Medicine, 10(2), 182-193.

1988

Berkelbach van der Sprenkel, J.W., Luyten, P.R., Rijen, P.C. van, Tulleken, C.A.F., &

Hollander, J.A. den (1988). Cerebral lactate detected by regional proton magnetic resonance spectroscopy in a patient with cerebral infarction. Stroke, 19(12), 1556-1560.

Berkelbach van der Sprenkel, J.W., & Tulleken, C.A. (1988). The postorbital approach to the

middle cerebral artery in cats. Stroke, 19(4), 503-506.

1987

Berkelbach van der Sprenkel, J.W., Lopes da Silva, F.H., Dieren, A. van, & Tulleken, C.A.

(1987). Topography and cortical generators of somatosensory potentials evoked by median nerve stimulation in the cat. Electroencephalography and clinical neurophysiology, 66(3), 299-306.

1986

Berkelbach van der Sprenkel, J.W., Mauser, H.W., Huynen, C.H., Kneepkens, R.H., &

Tulleken. C.A.F. (1986). MRI in neurosurgical diagnosis and management of craniocervical junction and cervical spine pathology. Clinical Neurology and Neurosurgery, 88(4), 245-251.

1985

Berkelbach van der Sprenkel, J.W., Timmermans, A.J., Elbers, H.R., Herpen, G. van, & Dinant,

H.J. (1985). Polyarthritis as the presenting symptom of a malignant fibrous histiocytoma of the heart. Arthritis and Rheumatism, 28(8), 944-947.